study the effects of malva sylvestris hydro-alcoholic extract onthecarrageenan-induced inflammation in male rat paw

background using chemical drugs have often masses of damaged side effects therefore,it is important to research about medicinal plants with anti-inflammation and fewer side effects.malvasylvestris has potential use as a medicinal plant. the aim of this study was to investigate the effect of malva sylvestris flowers hydroalcoholic extract on the carrageennan-induced inflammatory response using wistar male rats' paws material and methods malva sylvestris flowers powder wasmacerated with 70%ethanol, and its extract prepared. male wistar rats were divided into 6 groups of 10 animals each for following treatments: malva extract (200,400,600 and 800 mg/kg), normal saline (5mg/kg) as negative control and aspirin (300mg/kg) as a positive via ip.thirty min later inflammation was induced by injection of 100µlcarrageenan (1%w/v) into the rat's hind paw of rats(sc). the inflamation response changes were inspected over 5 hours every hour, using plethysmometer. results the extract-treated (600,800 mg/kg) showed considerable reduction in the rats' paws inflamation when compared with control groop(p>0.05). but 200 and 400 mg/kg extract showed no considerable decrease in inflamation when comparied with control group (p<0.05). there was not significant differences between doses of 600 and 800 mg/kg of extract, therfore dose of 600 mg/kg was selected as the most favorable dose as anti-inflamation.